Mixed
Administration of next-generation probiotics (NGP) such as Akkermansia muciniphila, Parabacteroides goldsteinii, and Christensenella minuta can ameliorate obesity and insulin resistance by modulating gut microbiota composition and enhancing intestinal barrier integrity.
Focus on dietary patterns that support the growth of specific beneficial bacteria like Akkermansia muciniphila (e.g., through prebiotics like inulin) rather than relying solely on standard probiotic supplements. While NGPs show promise in reversing obesity and insulin resistance in studies, they are not yet widely available as standardized treatments. Prioritize whole-food, fiber-rich diets to foster a healthy microbiome.
emerging next generation probiotics start to reveal as new preventive and therapeutic tools... reverse obesity and insulin resistance
Why this rating
Review article summarizing animal models and some human observational data; lacks large-scale RCTs for specific NGP dosing.
Source
Next generation probiotics in disease amelioration
Chih‐Jung Chang et al. · Journal of Food and Drug Analysis · 2019
DOI 10.1016/j.jfda.2018.12.011
Related findings · Mixed
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