Research
Macro partitioning
Caloric restriction (CR) reprograms the single-cell transcriptional landscape of aging, altering gene expression patterns in specific tissues.
Caloric restriction changes how genes are expressed in cells, particularly in rats. This database allows researchers to see exactly which genes are affected, potentially leading to drugs that mimic these benefits without strict dieting.
GoodSupportsHIGH confidence
This module also contains single-cell transcriptomic data... under caloric restriction (CR)... Caloric restriction reprograms the single-cell transcriptional landscape of Rattus norvegicus aging.
Why this rating
The paper cites specific high-impact studies (Ref 24) demonstrating this effect, though the paper itself is a database description.
Source
Aging Atlas: a multi-omics database for aging biology
Guang‐Hui Liu et al. · Nucleic Acids Research · 2020
narrative_reviewCited 337×
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