Micronutrients & recovery
Daily supplementation with vitamin D (400-800 IU) combined with calcium (1000-1200 mg) reduces the risk of hip fracture by 16% in older adults, whereas vitamin D alone provides no significant fracture protection.
If you are an older adult looking to prevent hip fractures, taking Vitamin D alone is likely ineffective. You should take a daily combination of Vitamin D (400-800 IU) and Calcium (1000-1200 mg). This specific combination has been shown to significantly reduce hip fracture risk, whereas Vitamin D by itself does not.
In contrast, a meta-analysis of 6 RCTs (49 282 participants, 5449 fractures, 730 hip fractures) of combined supplementation with vitamin D (daily doses of 400-800 IU, yielding a median difference in 25[OH]D concentration of 9.2 ng/mL) and calcium (daily doses of 1000-1200 mg) found a 6% reduced risk of any fracture (RR, 0.94; 95% CI, 0.89-0.99) and a 16% reduced risk of hip fracture (RR, 0.84; 95% CI, 0.72-0.97).
Why this rating
Based on a systematic review and meta-analysis of 6 large RCTs (n=49,282), though the authors note a high risk of bias in the included trials.
Source
Vitamin D and Calcium for the Prevention of Fracture
Pang Yao et al. · JAMA Network Open · 2019
DOI 10.1001/jamanetworkopen.2019.17789
Related findings · Micronutrients & recovery
- Trans fats (industrial trans-fatty acids) are unequivocally harmful and should be completely avoided as they raise LDL-C, TGs, and Apo B while lowering HDL-C.Strong
- For menopausal women with osteoporosis, first-line pharmacologic therapies include alendronate, risedronate, zoledronic acid, and denosumab for the prevention of hip, nonvertebral, and vertebral fractures.Strong
- Folic acid fortification of flour prevents neural tube birth defects, and mandatory fortification is more effective than voluntary supplementation alone.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →