Research

Micronutrients & recovery

Higher blood concentrations of 25-hydroxyvitamin D (25[OH]D) are associated with lower risks of fracture in observational studies, but this association is not replicated when using vitamin D supplementation alone in randomized trials.

Don't rely on Vitamin D alone to protect your bones. While people with naturally high Vitamin D levels have fewer fractures, taking Vitamin D supplements by themselves does not reduce fracture risk. You need to combine it with Calcium to see benefits.

GoodQualifiesHIGH confidence
In a meta-analysis of 11 observational studies... each increase of 10.0 ng/mL (ie, 25 nmol/L) in 25 (OH)D concentration was associated with an adjusted RR for any fracture of 0.93... and an adjusted RR for hip fracture of 0.80... A meta-analysis of 11 RCTs... of vitamin D supplementation alone... did not find a reduced risk of any fracture... or hip fracture.
Pang Yao et al. · JAMA Network Open · 2019

Why this rating

Based on 11 observational studies and 11 RCTs, providing robust data on the disconnect between blood levels and supplementation efficacy.

Source

Vitamin D and Calcium for the Prevention of Fracture

Pang Yao et al. · JAMA Network Open · 2019

Meta-analysis · 17 studiesCited 331×
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