Research
Micronutrients & recovery
Higher blood concentrations of 25-hydroxyvitamin D (25[OH]D) are associated with lower risks of fracture in observational studies, but this association is not replicated when using vitamin D supplementation alone in randomized trials.
Don't rely on Vitamin D alone to protect your bones. While people with naturally high Vitamin D levels have fewer fractures, taking Vitamin D supplements by themselves does not reduce fracture risk. You need to combine it with Calcium to see benefits.
GoodQualifiesHIGH confidence
In a meta-analysis of 11 observational studies... each increase of 10.0 ng/mL (ie, 25 nmol/L) in 25 (OH)D concentration was associated with an adjusted RR for any fracture of 0.93... and an adjusted RR for hip fracture of 0.80... A meta-analysis of 11 RCTs... of vitamin D supplementation alone... did not find a reduced risk of any fracture... or hip fracture.
Why this rating
Based on 11 observational studies and 11 RCTs, providing robust data on the disconnect between blood levels and supplementation efficacy.
Source
Vitamin D and Calcium for the Prevention of Fracture
Pang Yao et al. · JAMA Network Open · 2019
DOI 10.1001/jamanetworkopen.2019.17789
Meta-analysis · 17 studiesCited 331×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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