Energy balance
Mitochondrial fusion is associated with increased longevity and improved metabolic efficiency, whereas unopposed fission (fragmentation) is linked to oxidative stress, reduced ATP production, and accelerated aging phenotypes.
Maintaining mitochondrial health involves supporting the dynamic balance of fusion and fission rather than simply maximizing one process. While specific supplements or exercises are not detailed in this mechanism paper, the evidence suggests that conditions promoting mitochondrial fusion (like moderate caloric restriction or specific genetic pathways) are linked to longevity in model organisms. Focus on general metabolic health markers rather than targeting single mitochondrial proteins in isolation.
studies in C. elegans and D. melanogaster showed that increased mitochondrial fusion is associated with increased longevity... fragmentation of the mitochondrial network correlates with age... mitochondrial fragmentation is associated with increased oxidative stress, mitochondrial depolarization, and reduced ATP production
Why this rating
Evidence is largely from model organisms (yeast, worms, flies, mice) and cell lines; direct causal links in human lifespan are noted as limited.
Source
Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease
Yasmine J. Liu et al. · Mechanisms of Ageing and Development · 2020
DOI 10.1016/j.mad.2020.111212
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