Micronutrients & recovery
Mitophagy, the selective degradation of damaged mitochondria, is a critical quality control mechanism that promotes longevity in model organisms, and its decline contributes to the accumulation of dysfunctional mitochondria in aging.
Supporting mitochondrial quality control through healthy lifestyle habits (like exercise and caloric restriction) may naturally enhance mitophagy, as seen in model organisms. However, since this paper is a mechanism review, specific dosages or supplements for humans are not provided. Focus on maintaining overall metabolic health to support these natural quality control processes.
Interventions that boost mitophagy benefit health and longevity in multiple model organisms ranging from yeasts to mice... Inhibiting mitophagy... leads to an accumulation of dysfunctional mitochondria and compromises animals’ resistance to various types of stress
Why this rating
Strong evidence in model organisms (C. elegans, D. melanogaster, mice), but direct human clinical data is not provided.
Source
Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease
Yasmine J. Liu et al. · Mechanisms of Ageing and Development · 2020
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