Micronutrients & recovery
Mitophagy, the selective degradation of damaged mitochondria, is a critical quality control mechanism that promotes longevity in model organisms, and its decline contributes to the accumulation of dysfunctional mitochondria in aging.
Supporting mitochondrial quality control through healthy lifestyle habits (like exercise and caloric restriction) may naturally enhance mitophagy, as seen in model organisms. However, since this paper is a mechanism review, specific dosages or supplements for humans are not provided. Focus on maintaining overall metabolic health to support these natural quality control processes.
Interventions that boost mitophagy benefit health and longevity in multiple model organisms ranging from yeasts to mice... Inhibiting mitophagy... leads to an accumulation of dysfunctional mitochondria and compromises animals’ resistance to various types of stress
Why this rating
Strong evidence in model organisms (C. elegans, D. melanogaster, mice), but direct human clinical data is not provided.
Source
Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease
Yasmine J. Liu et al. · Mechanisms of Ageing and Development · 2020
DOI 10.1016/j.mad.2020.111212
Related findings · Micronutrients & recovery
- Trans fats (industrial trans-fatty acids) are unequivocally harmful and should be completely avoided as they raise LDL-C, TGs, and Apo B while lowering HDL-C.Strong
- For menopausal women with osteoporosis, first-line pharmacologic therapies include alendronate, risedronate, zoledronic acid, and denosumab for the prevention of hip, nonvertebral, and vertebral fractures.Strong
- Folic acid fortification of flour prevents neural tube birth defects, and mandatory fortification is more effective than voluntary supplementation alone.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →