Mixed
FMT shows promise in treating Inflammatory Bowel Disease (IBD), including Ulcerative Colitis (UC) and Crohn's Disease (CD), but efficacy is lower and more variable than in CDI, with clinical remission rates around 36-45% in systematic reviews.
For those with Ulcerative Colitis or Crohn's Disease who haven't responded well to standard treatments, FMT might be an option. While not as consistently effective as for C. diff, some patients do achieve remission, especially younger individuals. It requires careful consideration of the risks and benefits, and multiple treatments may be needed.
In this study, clinical remission after FMT was achieved in 54 (45%) of 119 patients... the pooled estimate for achieving clinical remission was 36.2%, when the case series were excluded... Although it might appear that FMT is more effective in CD or younger patients, the patient populations were significantly heterogeneous, limiting the applicability of these conclusions.
Why this rating
Based on systematic reviews and meta-analyses, but limited by small sample sizes, heterogeneity, and publication bias.
Source
Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives
Hyun Ho Choi et al. · Clinical Endoscopy · 2016
DOI 10.5946/ce.2015.117
More from this paper
- Fecal microbiota transplantation (FMT) is a highly effective treatment for recurrent Clostridium difficile infection (CDI), achieving significantly higher symptom resolution rates compared to standard antibiotic therapies alone.Good
- FMT can improve insulin sensitivity and increase butyrate-producing intestinal microbiota in patients with metabolic syndrome when lean donor stool is used.Limited
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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