Research
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Subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences, necessitating urgent public health responses even in the absence of overt clinical symptoms.
In areas where thiamine deficiency is common, ensure children receive adequate thiamine through diet or supplementation, even if they appear healthy, to protect their long-term brain development.
ModerateSupportsMEDIUM confidence
Urgent public health responses are warranted in high-risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences.
Why this rating
The paper cites 'research suggesting' but does not detail specific longitudinal studies, indicating a need for more data.
Source
Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs
Kyly C. Whitfield et al. · Annals of the New York Academy of Sciences · 2018
DOI 10.1111/nyas.13919
narrative_reviewCited 319×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Thiamine (Vitamin B1) is an essential micronutrient required for energy metabolism, and its deficiency leads to severe clinical disorders like beriberi and Wernicke-Korsakoff syndrome, particularly in populations relying on polished rice or facing food insecurity.Good
- Food fortification and thiamine supplementation are effective interventions for raising thiamine status and reducing infantile beriberi in high-risk regions, although trial data remains limited.Moderate
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