Research
Mixed
Omega-3 PUFAs can alleviate symptoms of Non-Alcoholic Fatty Liver Disease (NAFLD) and obesity by modulating gut microbiota and reducing hepatic lipid content.
For those with NAFLD or obesity, omega-3 supplementation (EPA/DHA) can help reduce liver fat and improve metabolic markers. This is achieved by modulating gut bacteria and reducing inflammation. It is a supportive strategy alongside lifestyle changes.
ModerateSupportsMEDIUM confidence
In patients with NAFLD, administration of high concentrations of omega-3 significantly increased the omega-3 index and absolute values of EPA and DHA in red blood cells (RBC) and reduced the RBC omega-6/omega-3 fatty acid ratio (P < 0:0001) [94].
Why this rating
Review article citing clinical studies and animal models.
Source
Associations among Dietary Omega‐3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity
Yawei Fu et al. · Mediators of Inflammation · 2021
DOI 10.1155/2021/8879227
narrative_reviewCited 317×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Dietary omega-3 polyunsaturated fatty acids (EPA, DHA, ALA) modulate gut microbiota composition by increasing beneficial bacteria (Bifidobacteria, Lactobacilli, Akkermansia) and decreasing pathogenic or pro-inflammatory bacteria (Enterobacteria, Firmicutes-to-Bacteroidetes ratio), thereby improving intestinal barrier function and reducing systemic inflammation.Moderate
- Omega-3 PUFAs reduce intestinal inflammation and immune response by inhibiting pro-inflammatory signaling pathways (NF-κB, MAPK) and promoting anti-inflammatory mediators (IL-10, SCFAs like butyrate).Moderate
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