Research
Mixed
Slowing fundamental biological processes of aging (e.g., inflammation, mitochondrial dysfunction) is a strategic approach to delay the onset of all major chronic diseases by a mean of 7 years, thereby increasing healthspan.
While specific 'anti-aging' drugs are not yet standard, the goal is to slow biological aging. Current best practice is to combine regular physical activity and healthy diet to target these fundamental processes.
ModerateSupportsMEDIUM confidence
The findings indicate that slowing aging would delay the age of onset of all major chronic diseases by a mean of 7 years, thus significantly increasing healthspan, quality of life, and the ability to remain productive in the workforce.
Why this rating
Based on microsimulation models and animal studies; human evidence is emerging but not definitive.
Source
Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity
Douglas R. Seals et al. · The Journal of Physiology · 2015
DOI 10.1113/jphysiol.2014.282665
narrative_reviewCited 306×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →