Mixed
Omega-3 polyunsaturated fatty acid (PUFA) supplementation significantly reduces hepatic fat content in NAFLD patients, though the optimal dose and long-term histological benefits remain undetermined.
High-dose Omega-3 supplements (0.83-13.7g/day) can significantly reduce liver fat in NAFLD patients with few side effects. However, the optimal dose is unknown, and it should be viewed as an adjunct to lifestyle changes, not a standalone cure, as long-term histological benefits are not yet established.
Nine eligible studies, involving 355 patients with NAFLD, which tested doses of omega-3 PUFA treatments between .83 and 13.7 g/d, showed significant reductions in hepatic fat content (without any significant side effects)
Why this rating
Based on a systematic review of 9 studies, but the effect size is small and optimal dosing is unknown.
Source
Nonalcoholic Fatty Liver Disease: A Novel Cardiometabolic Risk Factor for Type 2 Diabetes and Its Complications
Giovanni Targher et al. · The Journal of Clinical Endocrinology & Metabolism · 2013
DOI 10.1210/jc.2012-3093
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- Intrahepatic triglyceride content is a stronger determinant of insulin resistance and glycemic control than visceral adipose tissue or intramyocellular lipid content.Good
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