Hormonal
Hyperinsulinemia is the primary etiological driver of insulin resistance, obesity, type 2 diabetes, and cardiovascular disease, rather than a compensatory response to insulin resistance.
Focus on lowering baseline insulin levels through dietary changes (e.g., reducing refined carbohydrates and sugars) and increasing hepatic insulin clearance. This may prevent or reverse the progression to insulin resistance, obesity, and type 2 diabetes, as high insulin is the primary driver of these conditions.
It has even been proposed that hyperinsulinemia per se is primary and causes (and is not a consequence of) insulin resistance [13].
Why this rating
The paper is a review citing observational and animal studies; it lacks large-scale randomized controlled trials proving causality in humans for all endpoints.
Source
Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer
J. A. M. J. L. Janssen · International Journal of Molecular Sciences · 2021
DOI 10.3390/ijms22157797
More from this paper
- Continuous hyperinsulinemia (loss of pulsatile secretion) directly causes insulin resistance by downregulating insulin receptors and impairing downstream signaling.Good
- Hyperinsulinemia shifts the insulin-to-GH ratio towards insulin, suppressing Growth Hormone and IGF-I, which promotes fat accumulation and reduces energy expenditure.Moderate
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