Research
Hormonal
Hyperinsulinemia shifts the insulin-to-GH ratio towards insulin, suppressing Growth Hormone and IGF-I, which promotes fat accumulation and reduces energy expenditure.
Reducing insulin levels may restore the natural balance with Growth Hormone, potentially improving lipid breakdown and energy expenditure, aiding in obesity management.
ModerateSupportsMEDIUM confidence
This insulin–GH shift promotes energy storage and lipid synthesis and hinders lipid breakdown, resulting in obesity due to higher fat accumulation and lower energy expenditure.
Why this rating
Based on mechanistic reviews and observational data.
Source
Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer
J. A. M. J. L. Janssen · International Journal of Molecular Sciences · 2021
DOI 10.3390/ijms22157797
narrative_reviewCited 294×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Continuous hyperinsulinemia (loss of pulsatile secretion) directly causes insulin resistance by downregulating insulin receptors and impairing downstream signaling.Good
- Hyperinsulinemia is the primary etiological driver of insulin resistance, obesity, type 2 diabetes, and cardiovascular disease, rather than a compensatory response to insulin resistance.Moderate
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