Research
Hormonal
Continuous hyperinsulinemia (loss of pulsatile secretion) directly causes insulin resistance by downregulating insulin receptors and impairing downstream signaling.
Avoid constant snacking or continuous nutrient intake to preserve pulsatile insulin secretion. Pulsatile secretion is essential for maintaining insulin sensitivity and preventing receptor downregulation.
GoodSupportsHIGH confidence
Continuous and long-term exposure to insulin causes a reduction in the number of insulin receptors at the cellular surface by promoting internalization as well as degradation of insulin receptors [69].
Why this rating
Supported by multiple animal studies and human infusion studies cited in the review.
Source
Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer
J. A. M. J. L. Janssen · International Journal of Molecular Sciences · 2021
DOI 10.3390/ijms22157797
narrative_reviewCited 294×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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