Mixed
The health benefits of dietary polyphenols are not determined by the polyphenols themselves, but by the specific microbial metabolites (postbiotics) produced by an individual's gut microbiota, leading to significant inter-individual variability in health outcomes.
Don't just focus on eating polyphenol-rich foods; understand that your gut bacteria decide if those foods help you. Some people convert these compounds into powerful health-promoting metabolites (postbiotics), while others do not. This explains why the same diet affects people differently.
The two-way interaction between polyphenols and gut microbiota (i.e., modulation of GM by polyphenols and their catabolism by the GM) is determinant in polyphenols’ effects... The knowledge is updated and position is taken here on... the evidence between phenolic-derived postbiotics and health... to explain polyphenols’ effects.
Why this rating
The paper is a review highlighting that while mechanistic in vitro/animal data is strong, human clinical evidence for specific postbiotics is currently 'scarce and very limited'.
Source
Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes
Adrián Cortés‐Martín et al. · Molecular Nutrition & Food Research · 2020
DOI 10.1002/mnfr.201900952
More from this paper
- Polyphenols can modulate the gut microbiota composition (acting as prebiotics) by promoting the growth of beneficial bacteria like Lactobacilli and Bifidobacteria, while inhibiting others through antimicrobial activity.Good
- Specific gut microbiota metabotypes (such as Equol producers or Urolithin-A producers) are associated with distinct health outcomes, including potential benefits for menopausal symptoms, cardiovascular health, and inflammation, whereas non-producers may see no benefit or different effects.Moderate
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