Research
Mixed
Targeted modulation of mitochondrial function through drugs, exercise, diet, gene therapy, stem cell therapy, and physical therapy can prevent or treat skeletal muscle atrophy.
Consider a multi-faceted approach to managing muscle atrophy. Incorporate regular exercise and a balanced diet as foundational steps. For more severe cases, consult healthcare providers about other potential therapies like drug treatments or physical therapy.
GoodSupportsHIGH confidence
Targeted modulation of mitochondrial function is an effective measure to treat and prevent skeletal muscle atrophy...
Why this rating
Review of various therapeutic approaches with evidence from multiple studies.
Source
Mitochondrial dysfunction: roles in skeletal muscle atrophy
Xin Chen et al. · Journal of Translational Medicine · 2023
DOI 10.1186/s12967-023-04369-z
narrative_reviewCited 272×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Mitochondrial dysfunction acts as a primary driver of skeletal muscle atrophy by triggering catabolic signaling pathways that promote the expression of muscle atrophy genes and increasing oxidative stress.Good
- Inflammation and oxidative stress are crucial triggering factors in skeletal muscle atrophy, leading to increased proteolysis and reduced protein synthesis.Good
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