Research
Mixed
Inflammation and oxidative stress are crucial triggering factors in skeletal muscle atrophy, leading to increased proteolysis and reduced protein synthesis.
Manage stress and inflammation through lifestyle choices. Regular exercise, a healthy diet, and adequate sleep can help reduce oxidative stress and inflammation, supporting muscle health.
GoodSupportsHIGH confidence
More and more studies have shown that inflammation and oxidative stress play a crucial triggering role in the process of muscle atrophy [1, 24].
Why this rating
Review of multiple studies supporting the link.
Source
Mitochondrial dysfunction: roles in skeletal muscle atrophy
Xin Chen et al. · Journal of Translational Medicine · 2023
DOI 10.1186/s12967-023-04369-z
narrative_reviewCited 272×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Mitochondrial dysfunction acts as a primary driver of skeletal muscle atrophy by triggering catabolic signaling pathways that promote the expression of muscle atrophy genes and increasing oxidative stress.Good
- Targeted modulation of mitochondrial function through drugs, exercise, diet, gene therapy, stem cell therapy, and physical therapy can prevent or treat skeletal muscle atrophy.Good
Related findings · Mixed
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