Micronutrients & recovery
Centenarians exhibit enhanced cytochrome P450 (CYP) enzyme activity and anti-oxidative responses, evidenced by increased 8,9-EpETrE and decreased lipid peroxidation markers (9-HODE, 9-oxoODE).
Focus on supporting your body's natural enzymatic detoxification systems through a balanced diet rich in diverse nutrients, rather than relying on high-dose antioxidant supplements. The paper suggests that the *process* of metabolism and detoxification (CYP activity) is crucial for longevity.
Our data in centenarians support promotion of cellular detoxification mechanisms through specific modulation of the arachidonic acid metabolic cascade as we underpinned increased concentration of 8,9-EpETrE, suggesting enhanced cytochrome P450 (CYP) enzyme activity. Such effective mechanism might result in the activation of an anti-oxidative response, as displayed by decreased circulating levels of 9-HODE and 9-oxoODE...
Why this rating
Based on targeted LC-MS/MS analysis of a small subset of centenarians (n=12) for eicosanoids.
Source
Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism
Sebastiano Collino et al. · PLoS ONE · 2013
DOI 10.1371/journal.pone.0056564
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