Mixed
Longevity is associated with increased urinary excretion of phenylacetylglutamine (PAG) and p-cresol sulfate (PCS), which mirror changes in gut microbiota structure and composition.
Support your gut health with a diverse, fiber-rich diet that promotes a healthy microbiome. This study links specific gut-derived metabolites (PAG, PCS) to longevity, suggesting that a healthy gut ecosystem is a component of exceptional aging.
Lastly, we also revealed that the longevity process deeply affects the structure and composition of the human gut microbiota as shown by the increased extrection of phenylacetylglutamine (PAG) and p-cresol sulfate (PCS) in urine of centenarians.
Why this rating
Based on 1H-NMR profiling of urine from a larger subset of centenarians (n=92) and microbiota data from a subgroup.
Source
Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism
Sebastiano Collino et al. · PLoS ONE · 2013
DOI 10.1371/journal.pone.0056564
More from this paper
- Extreme human longevity (centenarian status) is characterized by a distinct metabolic phenotype involving decreased serum tryptophan, specific remodeling of glycerophospholipids and sphingolipids, and altered gut microbiota metabolite excretion (phenylacetylglutamine and p-cresol sulfate).Moderate
- Centenarians exhibit enhanced cytochrome P450 (CYP) enzyme activity and anti-oxidative responses, evidenced by increased 8,9-EpETrE and decreased lipid peroxidation markers (9-HODE, 9-oxoODE).Moderate
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