Mixed
Expert consensus identifies 14 biomarkers of aging suitable for use as outcome measures in human intervention studies, spanning physiological, inflammatory, functional, and epigenetic domains.
When designing an aging intervention study, use one or more of the 14 consensus biomarkers (IGF-1, GDF15, hsCRP, IL-6, muscle mass/strength, grip strength, TUG, gait speed, balance, frailty index, cognitive health, blood pressure, or DNA methylation/epigenetic clocks) as your primary outcome measures. These are validated by expert consensus for detecting changes in biological age.
Expert consensus identified 14 potential biomarkers of ageing which may be used as outcome measures in intervention studies. Future ageing research should identify which combination of these biomarkers has the greatest utility.
Why this rating
Based on a multi-round Delphi study with 60 expert panelists completing all rounds, providing high expert consensus.
Source
An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies
Giorgia Perri et al. · The Journals of Gerontology Series A · 2024
DOI 10.1093/gerona/glae297
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- Functional and physiological biomarkers are more suitable for medium- and long-term interventions (≥3 months) than acute or short-term interventions (<3 months).Good
- Blood-based inflammatory biomarkers (IL-6, TNF-α) are suitable for field testing using dry blood spot sampling, unlike DNA methylation-based biomarkers which require advanced laboratory processes.Good
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