Research
Mixed
Pharmacotherapy with orlistat or sibutramine combined with dietary modification is efficacious in reducing weight regain after initial weight loss.
If you have lost weight, maintaining it is hard. This review suggests that using FDA-approved weight loss medications like orlistat or sibutramine, alongside a healthy diet, can help prevent you from gaining the weight back. This is a valid strategy to consider if lifestyle changes alone are not enough.
GoodSupportsHIGH confidence
The results of the reviewed trials revealed that treatment with orlistat or sibutramine combined with dietary modification... were efficacious in reducing weight regain after weight loss treatment.
Why this rating
Based on a review of 42 RCTs, which is the second strongest level of evidence.
Source
Randomized Clinical Trials of Weight Loss Maintenance
Melanie T. Turk et al. · The Journal of Cardiovascular Nursing · 2009
DOI 10.1097/01.jcn.0000317471.58048.32
systematic_reviewCited 261×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Modest weight loss (5%-10% of initial weight) is associated with improvements in cardiovascular risk factors such as hypertension and dyslipidemia.Strong
- Adherence to physical activity routines is efficacious in reducing weight regain after weight loss treatment.Good
- Self-monitoring behaviors, specifically weighing oneself, are significantly related to maintaining weight loss.Good
Related findings · Mixed
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