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Energy balance
Exercise-induced PGC1α expression activates branched-chain amino acid (BCAA) metabolism, using BCAAs as an energy source in the TCA cycle, and increases the production of the myokine BAIBA.
During prolonged exercise, your muscles use BCAAs for energy. This process triggers the release of BAIBA, a molecule that helps improve metabolism in fat tissue and other organs. This highlights the systemic benefits of exercise beyond just muscle contraction.
GoodSupportsHIGH confidence
These data suggest that exercise-induced PGC1α expression activates BCAA metabolism (Figure 1) [20,21]. ... In turn, exercise-induced PGC1α increases BAIBA, GABA, and arginine levels in the skeletal muscle [24].
Why this rating
Supported by microarray analysis and metabolomic data in transgenic mice and human studies.
Source
Regulation of Skeletal Muscle Function by Amino Acids
Yasutomi Kamei et al. · Nutrients · 2020
DOI 10.3390/nu12010261
narrative_reviewCited 246×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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