Research
Energy balance
Caloric restriction and its mimetics (e.g., metformin, resveratrol, rapamycin) extend healthspan and lifespan by activating metabolic sensors (AMPK, SIRT1) that promote mitochondrial biogenesis and mitophagy.
Adopting habits that mimic caloric restriction, such as time-restricted eating or regular exercise, can activate protective cellular pathways. While strict CR is difficult, its mimetics (like exercise) are accessible and beneficial for long-term health.
GoodSupportsHIGH confidence
CR mimetics and exercise promote longevity in animal models by impacting on these pathways... some anti-aging drugs and CR mimetics, such as resveratrol and rapamycin, are also regulators or inducers of autophagy and mitochondrial biogenesis.
Why this rating
Supported by multiple animal studies and mechanistic reviews, though human longevity data is less definitive.
Source
Reconsidering the Role of Mitochondria in Aging
Marta González‐Freire et al. · The Journals of Gerontology Series A · 2015
DOI 10.1093/gerona/glv070
narrative_reviewCited 244×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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