Research
Energy balance
Defects in mitochondrial dynamics (fusion/fission) and mitophagy contribute to sarcopenia and frailty by allowing the accumulation of dysfunctional mitochondria.
Maintaining muscle mass through resistance exercise supports mitochondrial quality control. This helps prevent the accumulation of dysfunctional mitochondria that contributes to age-related muscle loss.
GoodSupportsHIGH confidence
Defects in mitochondria maintenance and turnover because of impaired biogenesis and/or defective removal are thought to contribute to the pathogenesis of complex diseases... Defective mitophagy is associated with sarcopenia.
Why this rating
Supported by multiple studies linking mitophagy defects to sarcopenia in mice and humans.
Source
Reconsidering the Role of Mitochondria in Aging
Marta González‐Freire et al. · The Journals of Gerontology Series A · 2015
DOI 10.1093/gerona/glv070
narrative_reviewCited 244×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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