Research
Macro partitioning
Obesity-induced infiltration of M1 macrophages into metabolic tissues (adipose, liver, muscle) drives chronic inflammation that directly causes insulin resistance by interfering with insulin signaling pathways.
For those with obesity, reducing the inflammatory burden on metabolic tissues is key. This involves strategies that reduce macrophage infiltration, such as weight loss and potentially anti-inflammatory dietary patterns, to improve insulin sensitivity.
GoodSupportsHIGH confidence
In the obese state, macrophages infiltrate the target organ, are activated to the M1 polarization state and produce abundant inflammatory cytokines, which negatively affect the transmission of insulin signals and increase the development of chronic inflammation, as well as insulin resistance [62–64].
Why this rating
This is a review paper summarizing multiple animal and human studies; while mechanistic evidence is strong, it is not a single primary clinical trial.
Source
Macrophages, Chronic Inflammation, and Insulin Resistance
Li He et al. · Cells · 2022
narrative_reviewCited 235×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →