Research
Macro partitioning
Depletion of Kupffer cells (liver macrophages) improves insulin signaling and hepatic insulin sensitivity in obese mice.
Targeting liver inflammation may be a viable strategy for improving insulin sensitivity, though current clinical applications of macrophage depletion are limited.
GoodSupportsHIGH confidence
Intravenous infusion of clodronate can selectively deplete Kupffer cells without affecting ATMs, which is found to enhance insulin signaling and hepatic insulin sensitivity significantly in the case of an HFD [104].
Why this rating
Based on animal studies cited in the review.
Source
Macrophages, Chronic Inflammation, and Insulin Resistance
Li He et al. · Cells · 2022
DOI 10.3390/cells11193001
narrative_reviewCited 235×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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