Research
Micronutrients & recovery
Nutrients involved in one-carbon metabolism (folate, B12, B6, choline, betaine) regulate DNA methylation by modulating the levels of the methyl donor S-adenosylmethionine (SAM) and the inhibitor S-adenosylhomocysteine (SAH).
Ensure adequate intake of B-vitamins, folate, choline, and methionine through diet to support healthy one-carbon metabolism. Do not assume that high-dose supplementation will automatically correct epigenetic markers, as tissue-specific responses vary and excess may not yield benefits.
ModerateSupportsMEDIUM confidence
Nutrients involved in one-carbon metabolism, namely folate, vitamin B12, vitamin B6, riboflavin, methionine, choline and betaine, are involved in DNA methylation by regulating levels of the universal methyl donor S-adenosylmethionine and methyltransferase inhibitor S-adenosylhomocysteine.
Why this rating
The paper is a review summarizing animal and in vitro studies, noting limited evidence in free-living humans.
Source
Nutritional influences on epigenetics and age-related disease
Lara K Park et al. · Proceedings of The Nutrition Society · 2011
DOI 10.1017/s0029665111003302
narrative_reviewCited 232×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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