Energy balance
Deletion of intestinal epithelial MyD88 in mice prevents diet-induced obesity and metabolic disorders by increasing energy expenditure and improving gut barrier function, an effect mediated by changes in gut microbiota composition.
This research suggests that the health of your intestinal lining and its interaction with gut bacteria play a critical role in whether your body stores fat or burns energy, especially when eating a high-fat diet. While this study used genetic modification in mice, it implies that maintaining gut barrier integrity and a healthy microbiome might be key strategies for preventing obesity-related metabolic issues.
We report that inducible intestinal epithelial cell-specific deletion of MyD88 partially protects against diet-induced obesity, diabetes and inflammation. This is associated with increased energy expenditure, an improved glucose homeostasis, reduced hepatic steatosis, fat mass and inflammation. Protection is transferred following gut microbiota transplantation to germ-free recipients.
Why this rating
High-quality animal model with mechanistic depth and microbiota transfer validation, but not human clinical data.
Source
Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status
Amandine Everard et al. · Nature Communications · 2014
DOI 10.1038/ncomms6648
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