Energy balance
Targeting intestinal epithelial MyD88 therapeutically reduces fat mass and inflammation even after obesity is established, suggesting a potential treatment for existing obesity.
This study suggests that even after obesity develops, interventions that support intestinal health and reduce inflammation might help reverse fat gain. For now, this translates to focusing on dietary patterns that support gut barrier integrity and a diverse microbiome, rather than waiting for specific pharmaceutical targets.
We found that the induction of IEC-MyD88 deletion after the onset of obesity rapidly and strongly reduced fat mass... we observed that fat mass remained significantly lower in IEC MyD88-KO mice and lasted until the end of the experimental period.
Why this rating
Strong animal model evidence for therapeutic efficacy, but lacks human translation.
Source
Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status
Amandine Everard et al. · Nature Communications · 2014
DOI 10.1038/ncomms6648
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