Research
Hormonal
Liraglutide improves beta-cell function (HOMA-S) in patients with type 2 diabetes, as indicated by a significant increase in HOMA-S compared to placebo.
This treatment helps your pancreas work better at producing insulin in response to blood sugar levels, which is a key factor in managing type 2 diabetes.
GoodSupportsHIGH confidence
Liraglutide treatment suggested an improved beta-cell function compared with placebo as indicated by increased HOMA-S (liraglutide, 17.2%, and placebo, -15.2%; P = 0.015)
Why this rating
Statistically significant result from a randomized controlled trial.
Source
The Effect of Liraglutide, a Long-Acting Glucagon-Like Peptide 1 Derivative, on Glycemic Control, Body Composition, and 24-h Energy Expenditure in Patients With Type 2 Diabetes
Helle Harder et al. · Diabetes Care · 2004
DOI 10.2337/diacare.27.8.1915
rct · n=33Cited 225×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Treatment with 0.6 mg/day of the long-acting GLP-1 derivative liraglutide for 8 weeks significantly improves glycemic control (reducing fasting glucose and HbA1c) in obese patients with type 2 diabetes without causing weight gain.Good
- Liraglutide treatment does not significantly alter 24-hour energy expenditure or substrate oxidation in patients with type 2 diabetes.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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