Research
Energy balance
Liraglutide treatment does not significantly alter 24-hour energy expenditure or substrate oxidation in patients with type 2 diabetes.
Taking liraglutide will not change how many calories you burn throughout the day. Your energy expenditure remains the same as if you were taking a placebo.
GoodRefutesHIGH confidence
Twenty-four-hour energy expenditure was unaffected by the treatment (liraglutide, -12.6 kJ/h, and placebo, -13.7 kJ/h; P = 0.799).
Why this rating
Measured via respiratory chamber (gold standard), but only for a short-term (3-day) assessment within the 8-week trial.
Source
The Effect of Liraglutide, a Long-Acting Glucagon-Like Peptide 1 Derivative, on Glycemic Control, Body Composition, and 24-h Energy Expenditure in Patients With Type 2 Diabetes
Helle Harder et al. · Diabetes Care · 2004
DOI 10.2337/diacare.27.8.1915
rct · n=33Cited 225×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Treatment with 0.6 mg/day of the long-acting GLP-1 derivative liraglutide for 8 weeks significantly improves glycemic control (reducing fasting glucose and HbA1c) in obese patients with type 2 diabetes without causing weight gain.Good
- Liraglutide improves beta-cell function (HOMA-S) in patients with type 2 diabetes, as indicated by a significant increase in HOMA-S compared to placebo.Good
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