Hormonal
Consumption of high-temperature cooked foods (grilled, fried, baked) significantly increases systemic Advanced Glycation End Products (AGEs), which promotes oxidative stress, inflammation, and endocrine disruption, particularly in women with PCOS.
Prioritize cooking methods like steaming, boiling, or stewing over grilling, frying, or baking. These high-temperature techniques create Advanced Glycation End Products (AGEs) that can disrupt hormones and increase inflammation. If you do cook with dry heat, marinate meats in acidic solutions (vinegar/lemon) which can reduce AGE formation, and avoid charring.
Women consuming a high HA diet had elevated levels of serum AGEs, testosterone, insulin, and oxidative stress, as compared to women on low AGE isocaloric diet. Dietary changes may contribute to alterations in PCOS and its symptoms, but are independent of anthropometric parameters [91].
Why this rating
The paper is a review citing multiple observational and animal studies; it lacks a single large-scale randomized controlled trial (RCT) establishing causality in humans, relying on pilot studies and mechanistic reviews.
Source
Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health
Vidhu Gill et al. · Biomolecules · 2019
DOI 10.3390/biom9120888
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- Infant formula milk contains significantly higher levels of Advanced Glycation End Products (AGEs), specifically CML, compared to breast milk, potentially predisposing infants to inflammation and metabolic issues.Moderate
- Vitamin D3 supplementation can attenuate the negative effects of AGEs in women with PCOS by down-regulating the AGE-RAGE interaction and supporting steroidogenesis.Moderate
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