Research
Energy balance
Weight loss interventions, including hypocaloric diets and exercise, modulate the metabolomic profile of obese individuals, potentially reversing or altering obesity-related metabolic signatures.
Weight loss through diet or exercise changes your metabolic profile. This means that losing weight can help reverse some of the metabolic abnormalities associated with obesity, such as insulin resistance and altered amino acid levels.
GoodSupportsHIGH confidence
The third block comprises three studies that used metabolomics to predict weight loss... and 11 randomized clinical trials (RCTs) aimed to assess the effects of weight loss interventions (both hypocaloric diet programs and exercise interventions) on the metabolomic profiles of overweight or obese human subjects.
Why this rating
Based on 11 RCTs and 3 predictive studies included in the review.
Source
Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies
Óscar Daniel Rangel-Huerta et al. · Metabolomics · 2019
DOI 10.1007/s11306-019-1553-y
systematic_reviewCited 223×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Obesity is metabolically heterogeneous, distinguished by metabolically unhealthy obese (MUHO) phenotypes exhibiting insulin resistance, inflammation, and altered metabolite profiles, versus metabolically healthy obese (MHO) phenotypes.Good
- Elevated levels of branched-chain amino acids (BCAAs) and aromatic amino acids, along with altered lipid profiles (e.g., elevated palmitic acid), serve as consistent metabolomic signatures of obesity and insulin resistance.Good
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