Research
Energy balance
Activation of PPARα by fibrate agonists (e.g., fenofibrate, ciprofibrate) reduces plasma triglycerides and LDL-C while increasing HDL-C, primarily by accelerating fatty acid oxidation and ketone body production in the liver.
Fibrates are a class of drugs that activate PPARα to lower bad cholesterol (LDL) and triglycerides while raising good cholesterol (HDL). They work by telling your liver to burn more fat for energy. While diet plays a role in activating these receptors, fibrates provide a potent, targeted activation for those with high lipid levels.
GoodSupportsHIGH confidence
In the fasting state, PPARα accelerates fatty acid formation caused by lipolysis influx in adipose tissue of the liver by regulating the expression of apolipoprotein, thus increasing plasma levels of high-density lipoprotein cholesterol (HDL-C) and reducing levels of low-density lipoprotein cholesterol (LDL-C)... Promoting mitochondrial or peroxisomal oxidation in the liver is also vital for PPARα action in protecting the liver from lipotoxicity.
Why this rating
Supported by multiple gene knockout studies and clinical trials with fibrates, though the paper is a review.
Source
PPARs as Nuclear Receptors for Nutrient and Energy Metabolism
Fan Hong et al. · Molecules · 2019
DOI 10.3390/molecules24142545
narrative_reviewCited 221×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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