Research
Energy balance
Activation of PPARβ/δ by agonists like GW501516 improves fatty acid oxidation and glucose utilization in skeletal muscle, shifting muscle fiber type from fast-twitch glycolytic to slow-twitch oxidative, thereby enhancing exercise capacity and metabolic flexibility.
PPARβ/δ activation helps muscles burn fat and sugar more efficiently and shifts them to be more endurance-oriented. While drugs like GW501516 show this effect in studies, they are not approved for human use. Exercise naturally activates this pathway.
ModerateSupportsMEDIUM confidence
PPARβ/δ plays a major role in improving glycolysis, glucose uptake, and glycogen storage and in decreasing gluconeogenesis... On the one hand, it boosts the conversion of type II fast-twitch glycolytic SKM to the fiber type I slow-twitch oxidative fibers by a PPARβ/δ agonist.
Why this rating
Supported by animal studies and cell models; clinical approval for GW501516 is not mentioned.
Source
PPARs as Nuclear Receptors for Nutrient and Energy Metabolism
Fan Hong et al. · Molecules · 2019
DOI 10.3390/molecules24142545
narrative_reviewCited 221×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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