Research

Micronutrients & recovery

Lipoic acid supplementation (300-1800 mg/day) may improve glycemic control, insulin sensitivity, and weight loss in obese or diabetic patients, but effects are marginal and may be negated without concurrent exercise.

If you choose to use lipoic acid for diabetes or obesity, expect only marginal benefits. Studies used doses between 300mg and 1800mg daily. Crucially, do not take it without exercise, as one study suggested it might worsen LDL atherogenicity in sedentary obese individuals. Combine it with physical activity for potential improvements in insulin sensitivity and modest weight loss.

ModerateConditionalMEDIUM confidence
lipoic acid supplementation may be beneficial to some degree in obesity and diabetes... when combined with exercise, this atherogenic effect was abolished and the supplementation was beneficial.
Daniyal Abdali et al. · Medical Principles and Practice · 2015

Why this rating

Mixed results across studies; some show benefit, others show no effect or potential harm without exercise.

Source

How Effective Are Antioxidant Supplements in Obesity and Diabetes?

Daniyal Abdali et al. · Medical Principles and Practice · 2015

narrative_reviewCited 213×
Read the paper

This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →