Energy balance
Mitochondrial impairment accelerates epigenetic aging, while enhancing mitochondrial biogenesis slows it, establishing a direct link between mitochondrial function and the rate of epigenetic aging.
Mitochondrial health is a key driver of epigenetic aging. Impairing mitochondria accelerates the epigenetic clock, while boosting mitochondrial biogenesis slows it. This suggests that interventions supporting mitochondrial function (like exercise or specific nutrients) may slow epigenetic aging, independent of DNA repair or telomere length.
The impairment of mitochondrial function in CCCP-treated cells was confirmed empirically... and these cells exhibited highly accelerated epigenetic aging.
Why this rating
Direct causal link established via pharmacological inhibition (CCCP) and enhancement (Bezafibrate) in primary human cells with empirical validation of mitochondrial status.
Source
The relationship between epigenetic age and the hallmarks of aging in human cells
Sylwia Kabacik et al. · Nature Aging · 2022
DOI 10.1038/s43587-022-00220-0
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