Research
Mixed
Epigenetic aging initiates early in life upon the loss of pluripotency during differentiation, and the epigenetic age of a tissue is largely determined by the composition of stem cells versus differentiated cells.
Epigenetic aging begins when cells lose their stem-like pluripotency and start differentiating. The overall epigenetic age of a tissue reflects the balance of young stem cells and older differentiated cells. Maintaining a healthy stem cell pool may help keep tissue-level epigenetic age lower.
GoodSupportsHIGH confidence
It is evident that the epigenetic clock starts ticking very early on from the point of differentiation... This age difference was further increased when these cell fractions isolated from another four independent donors were put to culture in vitro until confluence.
Why this rating
Strong evidence from multiple cell types and donors, but limited to in vitro differentiation models.
Source
The relationship between epigenetic age and the hallmarks of aging in human cells
Sylwia Kabacik et al. · Nature Aging · 2022
DOI 10.1038/s43587-022-00220-0
mechanism_onlyCited 213×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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