Mixed
The association between BMI and specific genetic loci (KCNQ1, ALDH2, MYL2) is significantly stronger in men than in women within East Asian populations.
For East Asian individuals, genetic risk factors for BMI may manifest more strongly in men than in women. This suggests that genetic counseling or risk assessment might need to account for sex differences, although lifestyle interventions remain the primary tool for weight management for both sexes.
The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women.
Why this rating
Statistically significant interaction tests (P for interaction) reported in a large meta-analysis.
Source
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
Wanqing Wen et al. · Human Molecular Genetics · 2014
DOI 10.1093/hmg/ddu248
More from this paper
- Genetic variants near KCNQ1, ALDH2/MYL2, ITIH4, and NT5C2 are significantly associated with Body Mass Index (BMI) in East Asian populations, explaining approximately 0.16% of BMI variation collectively.Strong
- The ALDH2 genetic variant (rs671) associated with BMI has an antagonistic effect with alcohol consumption, showing a BMI-increasing effect primarily among non-drinkers.Good
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