Mixed
The ALDH2 genetic variant (rs671) associated with BMI has an antagonistic effect with alcohol consumption, showing a BMI-increasing effect primarily among non-drinkers.
For East Asians with the ALDH2 variant, the genetic link to BMI appears to be stronger in those who do not drink alcohol. This suggests that alcohol consumption might interact with this specific genetic risk factor, potentially masking or altering its effect on body weight.
Our study suggested an antagonistic effect of alcohol consumption on the ALDH2–BMI association. The ALDH*1 BMI-increasing effect was mainly observed among non-drinkers.
Why this rating
Based on subset analyses of two specific studies (SGWAS and KCPS-II) with direct access to individual data, but not the full meta-analysis sample.
Source
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
Wanqing Wen et al. · Human Molecular Genetics · 2014
DOI 10.1093/hmg/ddu248
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- Genetic variants near KCNQ1, ALDH2/MYL2, ITIH4, and NT5C2 are significantly associated with Body Mass Index (BMI) in East Asian populations, explaining approximately 0.16% of BMI variation collectively.Strong
- The association between BMI and specific genetic loci (KCNQ1, ALDH2, MYL2) is significantly stronger in men than in women within East Asian populations.Strong
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