Hormonal
Resveratrol inhibits adipogenesis (fat cell formation) by down-regulating key transcription factors C/EBPα and PPARγ in pre-adipocytes.
Resveratrol may help prevent the formation of new fat cells by interfering with the genetic signals (PPARγ, C/EBPα) that tell stem cells to become fat cells. This effect is observed in cell and animal studies, particularly at higher concentrations (20-100 µM in vitro). While human bioavailability is low, its metabolites may still contribute to this anti-adipogenic effect.
A good consensus concerning the involvement of a down-regulation of C/EBPα and PPARγ in this effect has been reached.
Why this rating
Based on a review of multiple in vitro studies (cell lines) and animal models; lacks direct human clinical trial data for obesity reduction.
Source
Resveratrol: Anti-Obesity Mechanisms of Action
Leixuri Aguirre et al. · Molecules · 2014
DOI 10.3390/molecules191118632
More from this paper
- Resveratrol reduces de novo lipogenesis (fat synthesis) and fatty acid uptake in adipose tissue by inhibiting enzymes like FAS, ACC, and LPL.Moderate
- Resveratrol promotes apoptosis (programmed cell death) in mature adipocytes at high concentrations.Moderate
- Resveratrol enhances brown adipose tissue (BAT) thermogenesis and increases fatty acid oxidation in skeletal muscle and liver.Moderate
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