Research
Hormonal
Resveratrol promotes apoptosis (programmed cell death) in mature adipocytes at high concentrations.
At high concentrations, resveratrol can trigger the death of existing mature fat cells (apoptosis). This effect is seen in cell cultures but requires doses much higher than typical dietary intake. It is a potential mechanism for reducing fat cell number, distinct from preventing new fat cell formation.
ModerateSupportsMEDIUM confidence
Also, in vitro studies have demonstrated that resveratrol can increase apoptosis in mature adipocytes.
Why this rating
Based on in vitro studies; human relevance at dietary/supplemental doses is uncertain.
Source
Resveratrol: Anti-Obesity Mechanisms of Action
Leixuri Aguirre et al. · Molecules · 2014
DOI 10.3390/molecules191118632
narrative_reviewCited 203×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Resveratrol inhibits adipogenesis (fat cell formation) by down-regulating key transcription factors C/EBPα and PPARγ in pre-adipocytes.Moderate
- Resveratrol reduces de novo lipogenesis (fat synthesis) and fatty acid uptake in adipose tissue by inhibiting enzymes like FAS, ACC, and LPL.Moderate
- Resveratrol enhances brown adipose tissue (BAT) thermogenesis and increases fatty acid oxidation in skeletal muscle and liver.Moderate
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