Mixed
Regular glucosamine supplementation is associated with a statistically significant reduction in all-cause mortality (15% lower risk) and cause-specific mortality for cardiovascular disease, cancer, respiratory, and digestive diseases.
This observational study suggests that regular glucosamine use is linked to a lower risk of death from various causes, including heart disease and cancer. The authors propose this may be due to anti-inflammatory effects or metabolic changes similar to low-carb diets. However, because this is not a randomized trial, it does not prove glucosamine causes these benefits; users might simply have healthier lifestyles. It should not replace standard medical care for chronic diseases.
In multivariable adjusted analyses, the HRs associated with glucosamine use were 0.85 (95% CI 0.82 to 0.89) for all-cause mortality, 0.82 (95% CI 0.74 to 0.90) for CVD mortality, 0.94 (95% CI 0.88 to 0.99) for cancer mortality, 0.73 (95% CI 0.66 to 0.81) for respiratory mortality and 0.74 (95% CI 0.62 to 0.90) for digestive mortality.
Why this rating
Large prospective cohort (n=495,077) with extensive adjustment for confounders, but subject to residual confounding and immortal time bias inherent to observational data.
Source
Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study
Zhihao Li et al. · Annals of the Rheumatic Diseases · 2020
DOI 10.1136/annrheumdis-2020-217176
More from this paper
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →