Research
Mixed
Reduction in growth factor signaling, particularly the GH/IGF-1 pathway and cell cycle genes, is a transcriptional signature of aging in various tissues.
Aging is associated with reduced signaling from growth factors like IGF-1. Paradoxically, reducing this signaling (e.g., via genetic manipulation or drugs) can extend lifespan in many organisms, suggesting that lower growth factor signaling may be beneficial for longevity.
ModerateSupportsMEDIUM confidence
A number of studies report transcriptional signatures indicative of reduced cell growth and proliferation during ageing: expression of genes associated with cell growth is reduced in human and worm muscle tissue from older individuals
Why this rating
Supported by multiple studies but context-dependent.
Source
Gene expression hallmarks of cellular ageing
Stephen Frenk et al. · Biogerontology · 2018
DOI 10.1007/s10522-018-9750-z
narrative_reviewCited 198×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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