Hormonal
Acute high-intensity cycling exercise (70% VO2max for 60 minutes) causes a transient decrease in serum levels of the myokine PEDF, which normalizes within 120 minutes post-exercise, despite increased local secretion from contracting muscle cells.
If you perform 60 minutes of cycling at 70% of your maximum aerobic capacity, expect your blood levels of the protein PEDF to drop temporarily (up to 2 hours post-workout). This does not mean the exercise is ineffective; rather, it reflects complex distribution dynamics where the protein may be moving into tissues. Do not use a single post-workout blood test of PEDF to judge the efficacy of your training session.
measurement of PEDF serum level after 60 min cycling revealed a decrease 30 min post exercise (Fig. 3F) that was normalized after 120 min post exercise.
Why this rating
Validated in a small human cohort (n=8) with clear statistical significance (p<0.05) and confirmed by in vitro myotube models.
Source
Identification and Validation of Novel Contraction-Regulated Myokines Released from Primary Human Skeletal Muscle Cells
Silja Raschke et al. · PLoS ONE · 2013
DOI 10.1371/journal.pone.0062008
More from this paper
- Skeletal muscle cells secrete 52 novel myokines and 48 additional contraction-regulated myokines, expanding the known human skeletal muscle secretome beyond previously identified proteins like IL-6 and irisin.Strong
- Electrical pulse stimulation (EPS) of primary human myotubes increases the secretion of the myokine PEDF in vitro, even though mRNA expression levels remain unchanged, indicating post-transcriptional regulation.Good
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