Research
Hormonal
Skeletal muscle cells secrete 52 novel myokines and 48 additional contraction-regulated myokines, expanding the known human skeletal muscle secretome beyond previously identified proteins like IL-6 and irisin.
Exercise triggers the release of many more signaling proteins than previously known. While we focus on well-known ones like IL-6, this research confirms that muscle contraction triggers a complex, largely uncharted hormonal response that contributes to health benefits.
StrongSupportsHIGH confidence
Most interestingly, we identified 52 novel myokines which have not been described before to be secreted by skeletal muscle cells. For 48 myokines we show that their release is regulated by contractile activity.
Why this rating
Large-scale screening using cytokine antibody arrays across multiple donors, with validation of key candidates.
Source
Identification and Validation of Novel Contraction-Regulated Myokines Released from Primary Human Skeletal Muscle Cells
Silja Raschke et al. · PLoS ONE · 2013
DOI 10.1371/journal.pone.0062008
mechanism_only · n=13Cited 197×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Acute high-intensity cycling exercise (70% VO2max for 60 minutes) causes a transient decrease in serum levels of the myokine PEDF, which normalizes within 120 minutes post-exercise, despite increased local secretion from contracting muscle cells.Good
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