Research
Energy balance
SIRT3 protects against oxidative stress and hearing loss during aging by deacetylating and activating antioxidant enzymes (SOD2, IDH2) and components of the electron transport chain.
SIRT3 helps protect mitochondria from oxidative damage by activating antioxidant enzymes and the electron transport chain. This protection is crucial for maintaining hearing and overall cellular health during aging.
GoodSupportsHIGH confidence
SIRT3 plays a major role in suppressing reactive oxygen species (ROS) in mitochondria, the primary source of oxidative stress, by deacetylating antioxidant enzymes and components of the electron transport chain itself.
Why this rating
Supported by multiple studies in mice showing SIRT3's role in ROS suppression and hearing protection.
Source
Sirtuins, Aging, and Metabolism
Leonard Guarente · Cold Spring Harbor Symposia on Quantitative Biology · 2011
DOI 10.1101/sqb.2011.76.010629
book_chapterCited 197×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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