Research
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SIRT3 acts as a tumor suppressor by suppressing the Warburg effect and HIF-1alpha activation, thereby inhibiting tumor growth and progression.
SIRT3 helps prevent cancer by suppressing the Warburg effect, which is the tendency of cancer cells to rely on glycolysis. Maintaining high SIRT3 levels may help keep cells in a healthier metabolic state.
GoodSupportsHIGH confidence
Strikingly, overexpression of SIRT3 reversed the Warburg effect in different breast cancer cell lines. The above data demonstrate that SIRT3 may suppress the Warburg effect through the ROS-HIF-1alpha axis.
Why this rating
Supported by xenograft studies and cell line experiments.
Source
Sirtuins, Aging, and Metabolism
Leonard Guarente · Cold Spring Harbor Symposia on Quantitative Biology · 2011
DOI 10.1101/sqb.2011.76.010629
book_chapterCited 197×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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