Research

Mixed

Neuromuscular electrical stimulation (NMES) applied to critically ill patients in the ICU, added to usual care, is more effective than usual care alone for preventing skeletal-muscle weakness.

For ICU patients who cannot actively exercise due to sedation or critical illness, applying Neuromuscular Electrical Stimulation (NMES) to major muscle groups (like quadriceps) daily, starting from the first few days of admission, is a proven strategy to prevent muscle weakness. Ensure the device intensity is high enough to cause a visible muscle contraction. This should be done alongside standard medical care.

GoodSupportsHIGH confidence
NMES added to usual care proved to be more effective than usual care alone for preventing skeletal-muscle weakness in critically ill patients.
Nicola A. Maffiuletti et al. · BMC Medicine · 2013

Why this rating

Based on 8 RCTs with moderate-to-high methodological quality (PEDro scores 4-8), though heterogeneity prevented a full meta-analysis.

Source

Neuromuscular electrical stimulation for preventing skeletal-muscle weakness and wasting in critically ill patients: a systematic review

Nicola A. Maffiuletti et al. · BMC Medicine · 2013

DOI 10.1186/1741-7015-11-137

systematic_review · n=172Cited 195×
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DOI resolved against Crossref · corpus check 2026-06-10

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