Hormonal
Adiponectin replacement therapy reverses insulin resistance and reduces atherosclerosis in animal models of obesity and diabetes.
This paper highlights that low levels of the hormone adiponectin are linked to insulin resistance and atherosclerosis in obese individuals. While replacing adiponectin has shown promising results in animal studies, human treatments are not yet available. For now, maintaining a healthy weight and engaging in regular physical activity are the best ways to support your body's natural adiponectin levels.
A number of studies have shown that obesity, insulin resistance and atherosclerosis are accompanied by decreased adiponectin levels and that adiponectin replacement under experimental settings is able to diminish both insulin resistance and atherosclerosis.
Why this rating
Strong evidence from multiple transgenic mouse models and in vitro studies, but lacks human clinical trial data.
Source
Adiponectin and its role in the obesity-induced insulin resistance and related complications.
Martin Haluzı́k et al. · Physiological Research · 2004
DOI 10.33549/physiolres.930479
More from this paper
- Obesity is associated with decreased plasma adiponectin levels, which correlates with insulin resistance and an increased risk of type 2 diabetes.Strong
- Treatment with PPAR-gamma agonists (thiazolidinediones) increases circulating adiponectin levels, which may mediate their insulin-sensitizing effects.Good
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